The article tells about the most scandalous doping substance of the latter years, about the history of its creation. Here is the product information and commentary by an associate professor at the University of Wisconsin-Madison about the drug. Also the composition of the drug and course of admission.
Mildronate is an inhibitor of the biosynthesis of L-carnitine and its transport. In clinics, it is used as a modulator cellular energy metabolism, and is cardioprotective drug. Main goal the drug is delaying the course of production L-carnitine, which in turn is a key molecule in chains of oxidation of fatty acids, and its regulation in the vascular system. Mildronate can be a promising remedy in antiatherosclerotic treatment.
Although, there are still many questions about the drug as anabolic agents. We can say with confidence that he there is a clear mechanism of action that can help both in cardiac and in sports activities. According to Karen Kopachek, associate professor of pharmaceuticals at University of Wisconsin-Madison: “Meldonium or Mildronate is one and the same, inhibits L-carnitine transporting fatty acids into mitochondria, where they are burned for energy. For the body This is a very costly process. But by blocking the availability of L-carnitine, meldonium causes your mitochondria to metabolize glucose for obtaining energy, which is much easier for the body and requires less oxygen, “she explains. It reduces oxidative stress and cell damage, while your body uses energy more effectively.
- Description of the drug and the differences between meldonium and mildronate
- Structure:
- Analogs of Mildronate
- Beneficial features
- Mildronate in sports
- Mildronate as a remedy for heart health
- For weight gain
- Recovery
- For weight loss
- Do I need a recipe
- Bodybuilding Mildronate Effects
- The interaction of meldonium with other drugs, and precautions
- Mildronate and alcohol
- Side effects and contraindications
- Features, recommendations, application scheme of Mildronate athletes and doses
- Mildronate reviews
- Description of the drug and the differences between meldonium and mildronate
- Structure:
- Analogs of Mildronate
- Beneficial features
- Mildronate in sports
- Mildronate as a remedy for heart health
- For weight gain
- Recovery
- For weight loss
- Do I need a recipe
- Bodybuilding Mildronate Effects
- The interaction of meldonium with other drugs, and precautions
- Mildronate and alcohol
- Side effects and contraindications
- Features, recommendations, application scheme of Mildronate athletes and doses
- Mildronate reviews
Description of the drug and the differences between meldonium and mildronate
Meldonium, also known as Mildronate, was discovered Latvian chemist in the 1970s and had a pronounced improving action on cardiovascular. Most studies have been carried out on rodents. Due to lack of evidence, meldonium does not Approved by the FDA or in the European Union. It is mainly used in Russia, Ukraine and Eastern Europe, where it is sold without recipe.
Structure:
meldonium dihydrate. release form injection, capsules, syrup. Dosage of 250 mg of Meldonium 4 times a day. Iv injection 0.5-1 g once a day or IM 0.5 g 1-2 times a day.
1 ml of the injection contains 100 mg of meldonium.
Analogs of Mildronate
- Adexor;
- Adenosine;
- Adenocore;
- Atf-long;
- Hawthorn.
Beneficial features
Mildronate contributes to:
- lower blood lactate and urea;
- improve glycogen conservation: glycogen levels increase in cells during prolonged physical activity;
- increase endurance and aerobic ability of athletes;
- improving cardiac functional parameters activities;
- increased opportunities for physical work;
- increase recovery speed after maximum and submaximal loads;
- activating the central nervous system and protecting against stress.
Mildronate in sports
This is a drug with unproven positive. action, very widely used by famous athletes. The World Anti-Doping Agency (WADA) places this substance in category S4, as regulating hormones and modulators of metabolism. Mildronate was discovered in the blood of Maria Sharapova during the Open Australian Championship. Almost at the same time, another Russian the athlete was caught in the doping control at Mildronate. This substance was found in the circulatory system of the skater Catherine Beaver.
In the 1990s, meldonium became popular among Russian athletes because of its low cost. At that time it was almost the only drug that could afford athletes given the low overall economic situation in country.
“We used it during the most difficult microcycles,” – told a Russian swimmer during an interview with championat.com Galina Shivalova. “I felt its consequences. In fact, it’s easier to tolerate stress and increased endurance. ”
Mildronate as a remedy for heart health
Mildronate was originally conceived as a drug for treatment cardiovascular disease. Its main effect was associated with slowing down the expansion zone of dead cells, after suffering myocardial damage. It also improves blood flow in the ischemic cortex. brain and reduces the frequency of angina attacks. A drug used to treat angina pectoris, myocardial infarction and chronic heart failure.
For weight gain
Mildronate is not suitable for mass gain, and can only serve in as a means for recovery and energy catalyst stocks. Perhaps a drug and is capable of indirectly affect muscle gain, but this effect will soon total, extremely insignificant and completely inconspicuous.
Recovery
Mildronate improves athletic performance and reduces time recovery after training. But then again, it’s all gleaned from animal research.
For weight loss
To reduce weight and reduce body fat the drug is useless. Since its action is aimed at obtaining energy and increase stamina, in itself it is not fat burner, and is not able to reduce the amount of subcutaneous fat. Its advantage in losing weight is only an increase health, which will bring the result.
Do I need a recipe
For the purchase of a drug in the countries of the former CIS no recipe needed.
Bodybuilding Mildronate Effects
Meldonium increases intracellular metabolism and helps the body to achieve increased stamina during physical stress and high neuropsychological stress during competitions. For a bodybuilder, this drug does not represent much interest, and plays a supporting role in the doping list funds. On the contrary, for athletes who have in training the process is dominated by aerobic exercise, this drug may be quite useful.
The interaction of meldonium with other drugs, and precautions
Published studies also do not contain any information. on this important issue. “Patients with heart disease, for which this drug is intended to take often medicines, as well as over-the-counter medicines, herbs, and others additives, “says Kopachek.
Mildronate and alcohol
The use of alcohol does not affect the effect of the drug.
Side effects and contraindications
- hypersensitivity to the components of the drug;
- increased intracranial pressure (in violation of the venous outflow, intracranial tumors);
- pregnancy;
- lactation period;
- age up to 18 years (effectiveness and safety are not installed).
Features, recommendations, application scheme of Mildronate athletes and doses
Dosage and use in capsules
0.5-1.0 g twice a day before training, as 14-21 day course.
Dosage and administration in injections
Intramuscularly and intravenously once a day for 0.5 -1.0 g. Course admission – 10-14 days.
How often can I repeat the course
The course can be repeated every three weeks.
Mildronate reviews
Most doctors today say that the effectiveness of meldonium doubtful.
“We often used it, especially in cyclic sports, and sometimes in teams, “says the doctor of the Russian national football team Eduard Bezuglov. “However, its effectiveness is difficult to evaluate, since it is rarely used in isolation. In my practice, I never used it, because I believe that it does not give no benefits. Its theoretical effect is easily achievable, thanks to normal sleep and good nutrition. ”